Hospital Universitario Nuestra Seora de Candelaria

Unidad de Investigacin
  • D. Wesch, P. Miranda, D. Afonso-Oramas, M. Althaus, J. Castro-Hernndez, J. Dominguez, R. E. Morty, WG Clauss, T. Gonzlez-Hernndez, D. Alvarez de la Rosa and T. Giraldez*. The neuronal-specific SGK1.1 kinase regulates δ epithelial Na+ channel independently of PY motifs and couples it to phospholipase C signaling. Am J Physiol-Cell Physiol (2010) 299: C779-C790.
  • D. Afonso-Oramas, P. Barroso-Chinea, I. Cruz-Muros, D. lvarez de la Rosa, J. Castro-Hernndez, J. Salas-Hernndez, T. Giraldez and T. Gonzlez-Hernndez. The dopamine transporter is differentially regulated after dopaminergic lesion. Neurobiol. Disease (2010) 40:518-530.
  • D. Wesch, M. Althaus, P. Miranda, I. Cruz-Muros, M. Fronius, T. Gonzlez-Hernndez, W. G. Clauss, D. Alvarez de la Rosa and T Giraldez* (*corresponding autor). Differential N-termini in epithelial Na+ channel δ subunit isoforms modulate channel trafficking to the membrane. Am. J. Physiology, (2012) 302(6):C868-79
  • T. Giraldez*, P. Rojas and D. Alvarez de la Rosa. New roles for ENaC channels: the delta subunit takes the stage (*corresponding autor). Invited Review for AJP-renal Physiology (2012) 303:F328-38)
  • C. Aguilar, I. Hernndez-Daz, JF Navarro, TE Hughes, T. Giraldez and D. Alvarez de la Rosa. Identification of a permissive site for generating a functional fluorescente mineralocorticoid receptor (2012) Endocrinology. 153(7):3517-25
  • P. Krumm, T. Giraldez, D. Alvarez de la Rosa, W. G. Clauss, M. Fronius, M. Althaus. Garlic is a Natural Inhibitor of Epithelial Sodium Channels. Bioorganic and Medicinal Chemistry (2012) 20(13):3979-84.
  • P. Alvar, J. Fernndez-Orth, C. Gomis-Perez, A. Alberdi, A. Alaimo, M. S. Rodrguez, T. Giraldez, P. Miranda, P. Areso and A. Villarroel. Surface expression and subunit specific control of steady-state protein levels by the Kv7.2 helix A-B linker (2012) PlosONE 7(10):e47263.
  • I. Hernndez-Daz, T. Giraldez, S. Morales, E. Salido, C. M. Canessa, D. lvarez de la Rosa. Heterogeneous Nuclear Ribonucleoprotein A2/B1 is a Tissue-Specific Aldosterone Target Gene with Prominent Induction in the Rat Distal Colon (2012) Am. J. Physiol. EN PRENSA. PMID:23139218
  • T. Giraldez*, J. Dominguez and D. Alvarez de la Rosa. Roles of ENaC in the brain future perspectives and pharmacological implications. Current Molecular Pharmacology, 2012. Invited review. EN PRENSA (*corresponding autor)
  • Hernandez-Diaz I, Giraldez T, Arnau MR, Smits VAJ, Jaisser F, Farman N and Alvarez de la Rosa D. The mineralocorticoid receptor is a constitutive nuclear factor in cardiomyocytes due to hyperactive nuclear localization signals. Endocrinology 2010, in press (
  • Afonso-Oramas D, Cruz-Muros I, Alvarez de la Rosa D, Abreu P, Giraldez T, Castro-Hernandez J, Salas-Hernández J, Lanciego JL, Rodriguez M and Gonzalez-Hernandez T. Dopamine transporter glycosylation correlates with the differential vulnerability of midbrain dopaminergic cells in Parkinson’s disease. Neurobiol Disease (2009) 36: 494-508. (
  • T. Giraldez*, I. Cruz-Muros, D. Afonso-Oramas, V. García-Marín, P. Pagel, T. González-Hernández, D. Alvarez de la Rosa. Cloning and functional expression of a new epithelial sodium channel d subunit isoform differentially expressed in neurons of the human and monkey telencephalon. J Neurochem (2007), 102: 1304-1315 (*corresponding author)
  • Pec MK, Artwohl M, Fernandez JJ, Souto ML, Alvarez de la Rosa D, Giraldez T, Valenzuela-Fernández A and Díaz-González F (2007) Chemical modulation of VLA integrin affinity in human breast cancer cells. Exp Cell Res 313: 1121-1134.
  • T. Giraldez, Thomas E. Hughes and Frederick J. Sigworth (2005) Generation of functional fluorescent BK channels by random insertion of GFP variants. J. Gen. Physiol. 126, 429-38.