Hospital Universitario Nuestra Seora de Candelaria

Unidad de Investigacin
Genomic instability & cancer
Félix Machín
PhD
Félix Machín

Genomic instability leads to cancer. Also genomic instability promotes diversity of the malignant cells within the tumour. DNA damage and chromosome nondisjunction are the two major causes of gross instability. We aim to study both problems and their relationship with the life and death of the cell. We use the model organism Saccharomyces cerevisiae as well as actual tumour tissues to gain insights into the complexity of the maintenance of the integrity of the genome. We are also interested in drugs that affect the DNA and their effects on how the can reshape the genome.  

 

 

Grants

  • Search for genetic defects and chemical agents that cause anaphase bridges and study of their consequences for the cell progeny.
    01/01/2013 31/12/2015
    Instituto de Salud Carlos III (Fondo de Investigacin Sanitaria). PI12/00280.
  • Consequences of sister chromatid resolution failure on the life of the cell and search for resolution inhibitors.
    01/01/2010 31/12/2012
    Instituto de Salud Carlos III (Fondo de Investigacin Sanitaria). PS09/00106.
  • Carcinogenesis of multiple sporadic basocellular carcinoma.
    01/03/2008 - 01/03/2010
    Fundacin Canaria para la Investigacin y la Salud (FUNCIS). 06/24.
  • Genomic instability in the ribosomal DNA as a molecular marker in cancer.
    01/03/2008 - 01/03/2010
    Fundacin Canaria para la Investigacin y la Salud (FUNCIS). 06/21.
  • Characterisation of sister chromatid nondisjunction during metaphase-anaphase transition and its prevalence in cancer. Possible clinical and therapeutical applications.
    01/12/2007 31/12/2009
    Instituto de Salud Carlos III (Fondo de Investigacin Sanitaria). PI06/1211.
  • Characterisation of genetic factors involved in genomic stability of repetitive regions. Assessment of their contribution to genomic instability in Cancer and possible anti-tumour applications.
    15/12/2005 - 15/12/2007
    Programa Ramn y Cajal (Ministerio de Educacin y Ciencia). 1354.