|
Genomic instability & cancer |
Félix Machín
PhD
Genomic instability leads to cancer. Also genomic instability promotes diversity of the malignant cells within the tumour. DNA damage and chromosome nondisjunction are the two major causes of gross instability. We aim to study both problems and their relationship with the life and death of the cell. We use the model organism Saccharomyces cerevisiae as well as actual tumour tissues to gain insights into the complexity of the maintenance of the integrity of the genome. We are also interested in drugs that affect the DNA and their effects on how the can reshape the genome.
Grants
-
Search for genetic defects and chemical agents that cause anaphase bridges and study of their consequences for the cell progeny.
01/01/2013 – 31/12/2015
Instituto de Salud Carlos III (Fondo de Investigación Sanitaria). PI12/00280.
-
Consequences of sister chromatid resolution failure on the life of the cell and search for resolution inhibitors.
01/01/2010 – 31/12/2012
Instituto de Salud Carlos III (Fondo de Investigación Sanitaria). PS09/00106.
-
Carcinogenesis of multiple sporadic basocellular carcinoma.
01/03/2008 - 01/03/2010
Fundación Canaria para la Investigación y la Salud (FUNCIS). 06/24.
-
Genomic instability in the ribosomal DNA as a molecular marker in cancer.
01/03/2008 - 01/03/2010
Fundación Canaria para la Investigación y la Salud (FUNCIS). 06/21.
-
Characterisation of sister chromatid nondisjunction during metaphase-anaphase transition and its prevalence in cancer. Possible clinical and therapeutical applications.
01/12/2007 – 31/12/2009
Instituto de Salud Carlos III (Fondo de Investigación Sanitaria). PI06/1211.
-
Characterisation of genetic factors involved in genomic stability of repetitive regions. Assessment of their contribution to genomic instability in Cancer and possible anti-tumour applications.
15/12/2005 - 15/12/2007
Programa Ramón y Cajal (Ministerio de Educación y Ciencia). 1354.
|
|
