Hospital Universitario Nuestra Seora de Candelaria

Unidad de Investigacin
  • Casero C, Estvez-Braun A, Ravelo AG, Demo M, Mndez-lvarez S, Machn F.
    Achyrofuran is an antibacterial agent capable of killing Methicillin-resistant Vancomycin-intermediate Staphylococcus aureus in the nanomolar range.
    Phytomedicine. IN PRESS
  • Quevedo O, Garca-Luis J, Matos-Perdomo E, Aragn L, Machn F.
    Nondisjunction of a single chromosome leads to breakage and activation of DNA damage checkpoint in G2.
    PLoS Genet. 2012 Feb;8(2):e1002509.
  • Quevedo O, Garca-Luis J, Lorenzo-Castrillejo I, Machn F.
    No role of homologous recombination in dealing with β-lapachone cytotoxicity in yeast.
    Chem Res Toxicol. 2011 Dec 19;24(12):2106-8. Epub 2011 Nov 22.
  • Sperry J, Lorenzo-Castrillejo I, Brimble MA, Machn F. (2009)
    Pyranonaphthoquinone derivatives of eleutherin, ventiloquinone L, thysanone and nanaomycin A possessing a diverse topoisomerase II inhibition and cytotoxicity spectrum.
    Bioorg Med Chem. 17(20):7131-7.
  • Clemente-Blanco A, Mayn-Santos M, Schneider DA, Machn F, Jarmuz A, Tschochner H, Aragn L. (2009)
    Cdc14 inhibits transcription by RNA polymerase I during anaphase.
    Nature. 458(7235):219-22.
    Jimnez-Alonso S, Orellana HC, Estvez-Braun A, Ravelo AG, Prez-Sacau E, Machn F. (2008)
    Design and synthesis of a novel series of pyranonaphthoquinones as topoisomerase II catalytic inhibitors.
    J Med Chem. 51(21):6761-72.
  • Torres-Rosell J, De Piccoli G, Cordon-Preciado V, Farmer S, Jarmuz A, Machin F, Pasero P, Lisby M, Haber JE, Aragn L. (2007)
    Anaphase onset before complete DNA replication with intact checkpoint responses.
    Science. 315(5817):1411-5.
  • Machin F, Torres-Rosell J, De Piccoli G, Carballo JA, Cha RS, Jarmuz A, Aragon L. (2006)
    Transcription of ribosomal genes can cause nondisjunction.
    Journal of Cell Biology. 173(6):893-903.
  • Machin F, Torres-Rosell J, Jarmuz A, Aragon L. (2005)
    Spindle-independent condensation-mediated segregation of yeast ribosomal DNA in late anaphase.
    Journal of Cell Biology. 168(2):209-19.
  • Machn F, Paschos K, Jarmuz A, Torres-Rosell J, Pade C, Aragn L. (2004)
    Condensin regulates rDNA silencing by modulating nucleolar Sir2p.
    Curr Biol. 14(2):125-30.